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Thursday, July 18, 2013

What Are SNP Ambiguity Codes and What Do They Mean?

That's a good question.  In fact one that I had myself.  Here's what I found:

Apparently single nucleotide polymorphism (SNP) ambiguity codes were constructed by the International Union of Pure and Applied Chemistry (IUPAC) to denote nucleotide changes in SNPs.  Here is a table of the meaning of each code taken from the ENSEMBLE SNPView website.

IUPAC Code   Mnemonic    MeaningComplement
KKetoG or TM
MAminoA or CK
SStrongC or GS
WWeakA or TW
RPurineA or GY
YPyrimidine C or TR
Bnot AC, G, or TV
Dnot CA, G, or TH
Hnot GA, C, or TD
Vnot T or U     A, C, or GB
NanyG, A, T, or C    N

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